The Efficacy of Acetic Acid and Lugol’s Iodine Assisted Colposcopic Imaging in Cases with Anormal Pap Smear Test Results

Efficacy of Acetic Acid and Lugol’s Iodine Assisted Colposcopic Imaging

Abstract

Aim

This study was conducted to investigate the diagnostic efficacy of colposcopic imaging with Acetic Acid and Lugol’s Iodine in cases with abnormal pap smear test results.

Materials and Method

Hundred and five patients who presented to the xxxxx University Medical Faculty Hospital Gynecology Outpatient Clinic between 2017 and 2020 with abnormal pap smear results and whose biopsy was taken using colposcopic imaging were evaluated retrospectively.  The study included patients with Pap smear results indicating atypical squamous cells of undetermined significance (ASCUS), low grade squamous intraepithelial lesion (LSIL), or high grade squamous intraepithelial lesion (HSIL).

Result

19% (n=20) of the patients with abnormal pap smear test results were diagnosed with HGSIL, 43.8% (n=46) were diagnosed with LGSIL, and 37.1% (n=39) were diagnosed with ASCUS. As a result of the biopsy performed on these patients, chronic cervicitis was diagnosed in 48.6%, CIN 1 in 28.6%, and CIN 2-3 in 22.9%. Initially, Acetic Acid was applied during colposcopy. In detecting premalignant cervical lesions, aceto-white areas were determined to have a sensitivity of 74.1%, a positive predictive value of 65.6%, a specificity of 58.8%, and a negative predictive value of 68.2%. Upon application of Lugol’s Iodine, the sensitivity of areas with no uptake in detecting premalignant cervical lesions was 83.3%, while the positive predictive value was 61.6%, the specificity was 45.1%, and the negative predictive value was 71.9%.

Conclusion

We determined that colposcopic imaging with Acetic Acid is more accurate than Lugol’s Iodine for detecting cervical premalignant lesions in patients with abnormal pap smear test results.