AMINO ACID LEVELS IN PATIENTS WITH FIBROMYALGIA SYNDROME
AMINO ACID and FIBROMYALGIA
DOI:
https://doi.org/10.5281/zenodo.14032574Keywords:
Fibromyalgia, Amino acids, LS-MS/MSAbstract
GİRİİŞ
Fibromiyalji sendromu (FMS), yaygın kas-iskelet ağrısı, yorgunluk, uyku bozuklukları ve bilişsel semptomlarla karakterize kronik bir ağrı sendromudur ve hastaların uzun vadeli sağlık hizmeti aramasına neden olur. Kadınlarda daha yaygın olsa da, hastalığın kesin etiyopatogenezi net değildir ve mevcut biyomedikal ve psikososyal tedaviler birçok hasta için yetersizdir. Bu çalışma, FMS'li hastaların amino asit profil seviyelerini inceleyerek FMS'nin tanısında ve tedavisinde potansiyel olarak kullanılabilecek amino asitleri belirlemeyi amaçlamaktadır.
MALZEMELER VE YÖNTEMLER
Çalışmaya Fiziksel Tıp ve Rehabilitasyon Kliniğine başvuran 90 katılımcı (FMS tanısı almış kadın hastalar: n=45, yaş ortalaması= 42.80 ± 11.78 yıl; sağlıklı kontroller: n=45, yaş ortalaması= 39.60 ± 12.35 yıl) dahil edildi. Tüm katılımcılardan kan örnekleri alındı ve plazma aminoasit profilleri 8045 LC-MS/MS cihazı kullanılarak ölçüldü. Aminoasit profil parametrelerinin multivariate analizi yapıldı.
SONUÇLAR
Alanin, arginin, aspartik asit, sitrülin, glutamin, glutamik asit, glisin, histidin, lösin, izolösin, alloizolösin, fenilalanin, prolin, serin, tirozin, valin, alfa aminopimelik asit, hidroksi prolin, serotonin, 5-hidroksitriptamin, taurin, glutamin ve glutamik asidin ortalama plazma düzeyleri FMS hasta grubunda anlamlı olarak daha düşüktü (p <0,001). Buna karşılık, triptofan, sistin, anserin, argino süksinik asit ve gama amino bütirik asit düzeyleri FMS'li hastalarda anlamlı olarak daha yüksekti (p <0,001).
SONUÇLAR
FMS'li hastaların ve bunlara karşılık gelen sağlıklı kontrollerin amino asit profillerinde belirgin farklılıklar vardı. Bu bulgular, amino asitlerin FMS'nin patofizyolojisini aydınlatmada ve prognozunda, tedavisinde ve takibinde potansiyel biyobelirteçler olarak rolünü göstermektedir.
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