Effect of Prognostic Nutritional Index and Inflammatory Markers on Survival in Elderly Patients with Locally Advanced Rectal Cancer
DOI:
https://doi.org/10.5281/zenodo.10018104Keywords:
Radyoterapi, prognostik beslenme indeksi, rektal kanser, enflamatuar belirteçlerAbstract
SOYUT
Amaç: Bu çalışma, tedavi öncesi periferik kanda prognostik nutrisyonel indeks (PNI), nötrofil-lenfosit oranı (NLR), trombosit-lenfosit oranı (PLR) ve lenfosit-monosit (LMR) oranının prognostik değeri ve sağkalım etkilerini değerlendirmeyi amaçladı. lokal ileri rektal kanserli (ELARC) yaşlı (≥70) hasta sayısı.
Gereç ve Yöntem: 2010-2020 yılları arasında ameliyat öncesi veya ameliyat sonrası kemoradyoterapi (KRT) alan 86 ELARC dahil edildi ve tıbbi kayıtları retrospektif olarak incelendi. Tedavi öncesi bir hafta içinde tam kan sayımı ve kan biyokimya sayımları yapıldı. PNI, NLR, LMR ve PLR'yi içeren hematolojik parametreler, uzun vadeli toksisite, tümör evresinin düşürülmesi, pCR (patolojik tam yanıt), OS (genel sağkalım) ve DFS (hastalıksız sağkalım) ile ilişkili olarak analiz edildi.
Bulgular : Tek değişkenli analizde, düşük NLO, düşük PLR ve yüksek PNI değerleri artmış OS ile, yüksek LMR, düşük PLR ve yüksek PNI değerleri ise artmış DFS ile ilişkilendirilmiştir. Çok değişkenli analizde, düşük PLR, yüksek PNI değerleri, erkek cinsiyet ve daha genç yaş, artmış OS'yi öngörmek için bağımsız prognostik faktörlerdi ve yüksek LMR değerleri ve lenf nodu tutulumunun olmaması, artmış DFS için tek bağımsız prognostik faktörler olarak kaldı. PLR değeri düştükçe patolojik tümör yanıtının seviyesi arttı.
Sonuç: PNI ve PLR, ELARC'de OS için önemli bir bağımsız prognostik faktör olarak bulundu. LMR'nin DFS için önemli bir bağımsız prognostik faktör olduğu bulundu. PLR'nin OS ve evre küçültme için önemli bir bağımsız prognostik faktör olduğu da bulundu.
Anahtar kelimeler: Radyoterapi, prognostik beslenme indeksi, rektal kanser, inflamatuar belirteçler
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