Prognostik Nutrisyonel İndeksin ve Enflamatuar Belirteçlerin Lokal İleri Evre Rektal Kanserli Yaşlı Hastalarda Sağkalımı Üzerine Etkisi
DOI:
https://doi.org/10.5281/zenodo.10018104Anahtar Kelimeler:
Radyoterapi, prognostik beslenme indeksi, rektal kanser, enflamatuar belirteçlerÖzet
ÖZET
Amaç: Bu içermez, lokal ileri rektum kanseri (ELARC) olan yaşlı (yaş ≥70) hastalarda tedavi öncesi periferik kanda prognostik nutrisyonel indeksi (PNI), nötrofil-lenfosit oranı (NLR), trombosit-lenfosit oranı (PLR) ve lenfosit-monosit (LMR) elde edilmesi prognostik değeri ve sağkalım değerlendirmesi amaçlandı.
Gereç ve Yöntem: 2010'dan 2020'ye kadar ameliyat öncesi veya ameliyat sonrası kemoradyoterapi (KRT) alan 86 ELARC dahil edildi ve tıbbi kayıtları retrospektif olarak analiz edildi. Tedavi öncesi bir hafta içinde tam kan sayımı ve kan biyokimya sayımları yapıldı. PNI, NLR, LMR ve PLR'yi içeren hematolojik parametreler, uzun vadeli toksisite, tümör evresinin düşürülmesi, pCR (patolojik tam yanıt), OS (genel sağkalım) ve DFS (hastalıksız sağkalım) ile ilişkili olarak analiz edildi.
Bulgular: Tek değişkenli analizde, düşük NLO, düşük PLR ve yüksek PNI değerleri ağırlıklı OS ile; yüksek LMR, düşük PLR ve yüksek PNI değerleri ise, ağırlıklı DFS ile yapardı. Çok değişkenli analizde, düşük PLR, yüksek PNI değerleri, erkek cinsiyeti ve daha genç yaş, yoğun OS'yi öngörmek için bağımsız prognostik faktörlerdi ve yüksek LMR değerleri ve lenf nodu tutulumunun üzerinde, yoğun DFS için tek bağımsız prognostik faktörler olarak kaldı. PLR değeri düştükçe patolojik tümörün seyrinin seviyesi saptandı.
Sonuç: PNI ve PLR, ELARC'de OS için önemli bir bağımsız prognostik factor olarak bulundu. LMR'nin DFS için önemli bir bağımsız prognostik faktör olduğu bulundu. PLR'nin OS ve evreni küçültme için önemli bir bağımsız prognostik factor olduğu da bulundu.
Anahtar kelimeler: Radyoterapi, prognostik beslenme indeksi, rektal kanser, enflamatuar belirteçler
İndirmeler
Referanslar
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