Retrospective evaluation of child cases followed with the prediagnosis of Crimean-Congohemorrhagic fever

Abstract

Objective: The aim of our study is to evaluate the clinical, demographic and laboratory findings of the patients who were followed up with the diagnosis of Crimean-Congohemorrhagic fever (CCHF) in Gaziosmanpasa University Medical Faculty Child Health and Diseases Service. This study was carried out with the aim of observing the importance of early diagnosis, the effect of the supportive treatment we applied on shortening the hospital stay and preventing the development of complications.

Methods: The study was carried out in accordance with the Declaration of Helsinki Principles., the medical records of patients who had CCHF prevalence between January 2012 and July 2016 were reviewed retrospectively. Epidemiological, demographic and clinical characteristics of the cases, laboratory data, treatment modalities and results were extracted from the files.

Results: Between January 2012 and July 2016, a total of 100 patients with CCHF were detected. 52% of the patients came from rural areas. The most applications were in April and June (69%) months. 100% of the patients had a history of contact with ticks. The main symptoms and signs were fever (38%), haematological findings (34%), malaise (47%), abdominal pain (11%), headache (25%) and muscle pain (44%). At the time of admission to the hospital, 6% of patients had thrombocytopenia, 26% had leukopenia, 26% had high AST, 12% had high ALT, 44% had high LDH, 70% had high CPK, 8% ,Prolonged PTT in 28% and high INR in 13%. All patients underwent liquid-electrolyte therapy for support, 5% aphasic platelet suspension, 13% fresh frozen plasma, 12% repeated erythrocyte suspension, and 13% received ribavirin treatment. Our patients we were taking were discharged with healing.

Conclusion: Inconclusion, clinical manifestations of CCHF are similar to adults in children and CCHF is more favorable in children. There is no definitive treatment yet. And most of the treatment is supportive treatment.