The The Role of Inflammatory Markers in the Evaluation of Cerclage Success

Inflammatory Markers in the Cerclage Success

Abstract

cerclage success in patients who underwent a cerclage procedure.

Material and Methods: Pregnant women who had undergone McDonald cerclage were included in the study. Sixty-one pregnant women participated in the study, of whom 32 (52.46 %) underwent elective cerclage and 29 (47.54 %) emergency cerclage. Laboratory analysis determined neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and systemic immune inflammation index (SII). Patients undergoing cerclage were compared into two groups, elective and emergency cerclage groups.

Results: The mean gestational week for cerclage insertion was 13.41±0.83 weeks for elective cerclage and 17.45±4.37 weeks for emergency cerclage. No significant difference was found between the groups in terms of age, gravid, week of delivery, mode of delivery and neonatal outcomes (p>.05). However, a significant difference was found in the values for history of abortion, cervical length, and period from cerclage placement to delivery (p<.05). No significant difference was found between NLR, MLR, PLR, and SII values between the two groups in the study (p>.05), but a significant negative correlation was found between SII value and week of delivery (p<.05, r= -0.278).

Conclusion: The NLR, MLR, and PLR values were not found to be beneficial in predicting the success of the cerclage procedure in prolonging the duration of pregnancy. In contrast, the negative correlation between the SII value and the week of delivery proved to be inexpensive and easily determined prognostic marker that could be used to specify the success and prognosis of cervical cerclage.