Childhood osteosarcoma: The experience of a single center

Osteosarcoma in children


  • Sema Yilmaz Selcuk University School of Medicine Department of Pediatrics, Konya, Turkey
  • Buket Kara Selcuk University School of Medicine Department of Pediatrics, Division of Pediatric Hematology and Oncology, Konya, Turkey
  • Bahattin Kerem Aydin Selcuk University School of Medicine Department of Orthopaedics and Traumatology, Konya, Turkey
  • Zeliha Esin Celik Selcuk University School of Medicine Department of Pathology, Konya, Turkey
  • Yavuz Koksal Selçuk Üniversitesi, Tıp Fakültesi, Çocuk Hematoloji ve Onkoloji AD



osteosarcoma, child, prognosis


Aim: In this study, it was aimed to evaluate the clinical features, treatment approaches and outcomes of patients with childhood osteosarcoma.

Material and Method: From 2006 to 2022, the oncology files of patients with osteosarcoma diagnosed and treated at Selçuk University hospitals between 2006 and 2022 were retrospectively reviewed.

Results: In this period, 24 children with osteosarcoma were included in the study. The male/female ratio was 1/1. The patients' age ranged from 7.8 to 17.2 years (median, 13.9 years). The most common site was the femur (n: 14, 58.3%). The follow-up period of the patients ranged from 9 months to 16.2 years (median, 3.15 years). Eight patients (33.4%) died with progressive disease. Overall and event-free survival rates were 58.6% ± 11.7% and 61% ± 10.2%, respectively. A negative effect of lactate dehydrogenase enzyme elevation at the time of diagnosis was observed on the overall survival rate (p=0.021). Although the overall survival rate was low in patients with metastatic disease at the time of diagnosis, the difference was not statistically significant (p=0.059).

Conclusion: Survival rates similar to those in osteosarcomas with localized disease, unfortunately, still cannot be achieved in metastatic osteosarcomas, which remains a serious problem. Therefore, new treatment approaches are needed in patients with metastatic osteosarcoma.


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How to Cite

Yilmaz, S., Kara, B. ., Aydin, B. K., Celik, Z. E., & Koksal, Y. (2023). Childhood osteosarcoma: The experience of a single center: Osteosarcoma in children . Chronicles of Precision Medical Researchers, 4(2), 126–130.

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