The Effect of Risk Factors on Mortality in Central line associated-bloodstream infections Developing in the Intensive Care Unit
DOI:
https://doi.org/10.5281/zenodo.12805654Keywords:
Central venous catheter-related bloodstream infection, healthcare-related infection, mortality, APACHE 2.Abstract
Aim
Central venous catheters (CVCs) are common used for treatment and monitoring in intensive care units. Despite beneficial effects CVC can lead to infectious complications. Central line associated-bloodstream infection (CLABSI) is one of the most common complications of CVC.
Materials and Methods
From 2017 to 2021, a total of 245 patients aged 18 years and older who had developed CVC-BSI and had been admitted to all intensive care units of the hospital were retrospectively evaluated. Patient age, gender, comorbidities, length of stay in the ICU, ICU unit monitored, use of total parenteral nutrition (TPN), isolated microorganism, infection rate, and APACHE 2 score were evaluated.
Results
From 2017 to 2021, a total of 245 patients aged 18 years and older who had developed CVC-BSI and had been admitted to all intensive care units of the hospital were retrospectively evaluated. 171 of 245 patients were 65 years or older. There was a significant difference between being 65 years of age and older and mortality (p:0.002). There was a significant relationship between female gender and mortality (p:0.045). Fifty-seven patients (%32) had femoral catheters, 117 (%65.7) had subclavian/jugular catheters, and 4 (%2.2) had hemodialysis catheters. The study found no significant relationship between the site of CVC insertion and mortality (p:0.539). Likewise, no significant difference was found between TPN use, secondary infection development, and mortality. While gram-negative bacteria were the most commonly isolated pathogens, CNS (coagulase-negative staphylococcus) was the most commonly isolated microorganism in CVC-BSI.
Conclusion
Central venous catheter-related infections, particularly CVC-BSI, are common and life-threatening infections in intensive care units. It was found that this type of infections particularly increases mortality in female and geriatric patient groups. However, it was revealed that the APACHE 2 score, catheter site, and TPN use are not effective on mortality.
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