The Effect of Quercetin Against Oxidative Stress and Possible Histopathological Changes Caused by Bisphenol-A Exposure in Rat Ovary

Effect of quercetin against BPA exposure in the ovary


  • Yılmaz koçak Van Yuzuncu Yil University, Faculty of Health Sciences, Physical Therapy and Rehabilitation, 65080, Tuşba, Van, Turkey
  • Fikret Altindag Van Yuzuncu Yil University, Faculty of Medicine, Department of Histology and Embryology
  • Emine Okumuş Van Yuzuncu Yil University, Faculty of Engineering, Department of Food Engineering, 65080, Tuşba, Van, Turkey
  • Gokhan Oto Van Yuzuncu Yil University, Faculty of Medicine, Department of Pharmacology, 65080, Tuşba, Van, Turkey
  • Mehmet Hafit Bayir Van Yuzuncu Yil University, Faculty of Medicine, Department of Histology and Embryology
  • Seray Alparslan Van Yuzuncu Yil University, Faculty of Medicine, Department of Pharmacology, 65080, Tuşba, Van, Turkey



Ovarium, Oxidative stress, Bisphenol A, Quercetin, Rat




Aim: Endocrine-disrupting chemicals can have adverse effects on the reproductive system. One of these chemicals, bisphenol A (BPA), due to its estrogenic effects, is believed to trigger oxidative stress and potentially disrupt ovarian functions, leading to a reduction in fertility, particularly in females. In this study, the possible histopathological effect of BPA, which possesses endocrine-disrupting properties, on the ovaries of female rats, and the investigatory role of quercetin (Q) in mitigating oxidative stress induced by BPA exposure were aimed to be determined.

Material and Method: In this study, 32 female Wistar albino rats were used, and 4 groups were formed as control (corn oil, p.o.), BPA (10 mg/kg p.o.), Q (15 mg/kg i.p.) and BPA+Q. After the rats were sacrificed, histopathological changes in ovarian tissues and Malondialdehyde (MDA), Catalase (CAT), advanced oxidation protein products (AOPP), and glutathione (GSH) levels were analyzed spectrophotometrically.

Results: The results of the study, which lasted a total of 14 days, showed that BPA caused changes in the ovarian tissues of female rats.  The results of biochemical and histopathological analysis determined that quercetin administration ameliorated the adverse effect of BPA. BPA administration showed a significant increase in the levels of MDA and AOPP, biomarkers of oxidative stress. Moreover, antioxidant enzyme levels (CAT and GSH were increased by quercetin administration.

Conclusion: BPA may induce oxidative stress in ovarian tissues of female rats, leading to histopathologic changes. On the other hand, quercetin treatment showed a protective effect by significantly reducing the debilitating effects of BPA on the reproductive system.


Keywords: Ovarium, Oxidative stress, Bisphenol-A, Quercetin, Rat.



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How to Cite

koçak, Y. ., Altindag, F., Okumuş, E. ., Oto, G. ., Bayir, M. H. ., & Alparslan, S. (2023). The Effect of Quercetin Against Oxidative Stress and Possible Histopathological Changes Caused by Bisphenol-A Exposure in Rat Ovary : Effect of quercetin against BPA exposure in the ovary . Chronicles of Precision Medical Researchers, 4(3), 290–296.