Pentraxin-3 ve Trpm2 Aracılı Olan Hidroksitirozolun Akciğer Hasarı Üzerindeki Koruyucu
Hidroksitirosolün Koruyucu Etkisi
DOI:
https://doi.org/10.5281/zenodo.10019760Anahtar Kelimeler:
Miyokard İnfarktüsü, akciğer, Hidroksitirozol, PTX3, TRPM2.Özet
Amaç: Bu çalışmada Miyokard İnfarktüsü (MI) öncesi sıçanlara Hidroksitirozol (HT) uygulanarak MI'da akciğerler üzerindeki koruyucu etkisinde Pentraxin-3 (PTX3) ve Geçici Reseptör Potansiyeli (TRP) Melastatin Benzeri Alt Aile Üyesi 2'nin (TRPM2) rolü araştırılmıştır.
Gereç ve Yöntem: Sıçanlar 4 gruba (n=7) ayrıldı (Kontrol, MI 6. saat, MI 7. gün, MI+HT 7. gün) ve MI oluşturmak için sıçanlara 200 mg/kg Isoproterenol (ISO) cilt altı uygulandı. Sıçanlara MI'dan önce 6 hafta boyunca ağızdan 4 ml/kg/gün HT içeren sıvı verildi. Akciğer dokularındaki PTX3 ve TRPM2 düzeyleri immünohistokimyasal olarak değerlendirildi.
Bulgular: Akciğer dokusunda PTX3 ve TRPM2 ekspresyonu tespit edildi. PTX3 ve TRPM2 düzeyleri özellikle MI sonrası 7. günde artarken, MI öncesi HT uygulamasını takiben 7. günde anlamlı düşüş gösterdi.
Sonuç: Bu çalışmada HT'nin MI'da akciğerler üzerindeki koruyucu etkisini PTX3 ve TRPM2 aracılığıyla gösterebileceği sonucuna varıldı.
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