Comparative Effects of Propofol and Etomidate on Postoperative Outcomes in Off-Pump Coronary Artery Bypass Grafting: A Retrospective Study

Propofol and Etomidate in Off-Pump Coronary Artery Bypass Grafting


  • muhammet ahmet karakaya acibadem atasehir hospital
  • Kamil Darcin Specialist of Anesthesiology and Reanimation, Department of Anesthesiology and Reanimation, Koc University Hospital, Istanbul, Turkey



Coronary Artery Bypass, Off-Pump, Propofol, Etomidate, Hospitalization



Cardiac surgeries often necessitate potent anaesthetic agents to optimize perioperative outcomes. This study aimed to evaluate and compare the postoperative effects of Propofol and Etomidate, two widely used anaesthetic agents, following Off-pump Coronary Artery Bypass Grafting (CABG).

Materials and Methods:
We conducted a retrospective review of patients who underwent off-pump CABG at Koç University Hospital from January 2018 through December 2021. Primary and secondary outcomes included the duration of Intensive Care Unit (ICU) stay, time to extubation post-surgery, and overall duration of hospitalization. Statistical analyses employed the Kolmogorov-Smirnov test, Independent Samples t-test, Chi-squared test, and Mann-Whitney U test.

Data from 66 patients were assessed, with 36 receiving Propofol and 30 receiving Etomidate during the induction phase of anaesthesia. No significant demographic or anthropometric differences existed between the groups. The median ICU stay for Propofol recipients was 1 day, while Etomidate recipients had a median stay of 1.5 days. The time to extubation post-surgery was 8 hours for Propofol and 6 hours for Etomidate. Both groups had a similar median hospitalization duration of 6 days. There were no statistically significant differences between groups for any of the outcomes.

The study found marginal differences in postoperative outcomes between Propofol and Etomidate users undergoing CABG. Both anaesthetics demonstrated comparable efficacies concerning ICU stay, extubation time, and overall hospitalization duration. Further prospective studies with larger cohorts are suggested to consolidate these findings and refine anaesthesia strategies in cardiac surgical contexts.


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How to Cite

karakaya, muhammet ahmet, & Darcin, K. (2023). Comparative Effects of Propofol and Etomidate on Postoperative Outcomes in Off-Pump Coronary Artery Bypass Grafting: A Retrospective Study: Propofol and Etomidate in Off-Pump Coronary Artery Bypass Grafting. Chronicles of Precision Medical Researchers, 4(3), 351–354.