Protective Effects of Hydroxytyrosol Mediated by Pentraxin-3 and Trpm2 on Lung Damage
The Protective Effect of Hydroxytyrosol
DOI:
https://doi.org/10.5281/zenodo.10019760Keywords:
Myocardial Infarction, lung, Hydroxytyrosol, PTX3, TRPM2.Abstract
Aim: The role of Pentraxin-3 (PTX3) and Transient Receptor Potential (TRP) Melastatin-Like Subfamily Member 2 (TRPM2) in its protective impacts on the lungs in MI by administering Hydroxytyrosol (HT) to rats before Myocardial Infarction (MI) were investigated in the study.
Materials and Methods: The rats were divided into 4 Groups (n=7) (Control, MI 6th-hour, MI 7th-day, MI+HT 7th-day), and 200mg/kg Isoproterenol (ISO) was given subcutaneously to the rats to induce MI. The rats were given fluid containing HT 4 ml/kg/day orally for 6 weeks before MI. PTX3 and TRPM2 levels in the lung tissues were evaluated immunohistochemically.
Results: PTX3 and TRPM2 expression was detected in the lung tissue. PTX3 and TRPM2 levels increased especially on the 7th day following MI, and declined significantly on the 7th day following HT administration before MI.
Conclusion: It was concluded in the present study that HT may exert its protective impacts on the lungs in MI through PTX3 and TRPM2.
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