Brucellosis: Are There Any Affect of Bacteraemia on Clinical Outcome

emsal aydın; Bircan  Ünal Kayaaslan; Aliye Baştuğ; Sergülen Aydın; Pınar Öngürü; Ayten Kadanalı; Hürrem  Bodur; Feyza YILDIZ AYTEKİN

doi:10.5281/zenodo.10018962

Authors

emsal aydın giresun üniversitesi
Bircan Ünal Kayaaslan Department of Infectious Diseases and Clinical Microbiology, Ankara Numune Training and Research Hospital, Ankara, Turkey
Aliye Baştuğ Department of Infectious Diseases and Clinical Microbiology, Ankara Numune Training and Research Hospital, Ankara, Turkey
Sergülen Aydın Department of Family Medicine, Faculty of Medicine, Kafkas University, Kars, Turkey
Pınar Öngürü Department of Infectious Diseases and Clinical Microbiology, Ankara Numune Training and Research Hospital, Ankara, Turkey
Ayten Kadanalı Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Kafkas University, Kars, Turkey
Hürrem Bodur Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Kafkas University, Kars, Turkey
Feyza YILDIZ AYTEKİN Ministry of Health Prof. Dr. A. Ilhan Özdemir state Hospital, Department of Infectious Diseases and Clinical Microbiology, Giresun https://orcid.org/0000-0002-9526-0707

DOI:

https://doi.org/10.5281/zenodo.10018962

Keywords:

Brucellosis, Bacteriemia, Clinical finding, Laboratory finding

Abstract

ABSTRACT

Introduction: In our study, we aimed to evaluate the epidemiological, clinical, serological and prognostic features of bacteremic and non-bacteremic brucellosis based on our clinical experience in patients presenting with brucellosis.

Material and Method: The study was carried out retrospectively in two different hospitals providing tertiary health care in Turkey. The data were obtained from the hospital information network of the centers. Patients over the age of 18 who were diagnosed with brucellosis during screening and hospitalized were included in the study.

Results:The data of 422 patients were included in the study. While 170 patients had positive culture results for Brucella spp., the results of 252 patients for Brucella spp. were negative. The number of patients with fever was higher in bacteremic patients (P= 0.035). Significant elevation of AST (P<0.001), ALT (P<0.001), CRP ((P=0.003) levels, leukopenia (P=0.006), and pancytopenia (P=0.006) were detected in bacteremic patients. The existence of complications was 50.4% in nonbacteremic patients and 38.2% in bacteremic patients (P=0.014). Agglutination titers of 1/1280 or greater were detected in 129 (51.2%) culture negative and 106 (62.4%) culture-positive cases (P=0.024). In multivariate analysis, leukopenia and elevated AST level were found to be the predictor of bacteremia in patients. Commonly used antimicrobial regimens consisted of doxycycline plus streptomycin or doxycycline plus rifampicin given for 6 weeks. The most common way of transmission (68.2 %) was the ingestion of milk products from diseased animals.

Conclusion: Bacteraemia was detected in 40.3 % of patients. The existence of bacteremia was positively correlated with fever, higher levels of ALT, AST, CRP leukopenia, and pancytopenia, and inversely with the rate of complication and relapses.