Evaluation of the Relationship between Laboratory Parameters and Allergy Tests in Children with Atopic Dermatitis

Laboratory Parameters and Allergy Tests in Children with Atopic Dermatitis

Abstract

Aim: The aim of this study was to evaluate the relationship between neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), eosinophil lymphocyte ratio (ELR), serum total IgE values and allergy test positivity among children with atopic dermatitis (AD).

Material and Method: The study is a case-control type study in a retrospective design. Children aged 0-18 years, diagnosed with AD, who applied to the pediatric allergy and immunology outpatient clinic of our hospital were included as the patient group. Children aged 0-18 years, who did not have any chronic diseases and applied to the pediatrics outpatient clinic of our hospital, were included as the control group. Children's sociodemographic characteristics, hemogram parameters, total IgE values, allergy history and allergy test positivity were evaluated. p<0.05 was accepted as statistical significance level.

Results: The data of 193 children with AD were evaluated. 100 children were included as a control group. Eosinophil, lymphocyte, total IgE, ELR values were significantly higher in the patient group than in the control group (p<0.05). The median values of PLR and ELR were higher in patients with allergy test positivity, but there was no statistical significance between the groups (p=0.268 and p=0.251, respectively). As the total IgE values were examined, the median total IgE value of the patients with a positive allergy test was 168.0 (2.0-6098.0), while this value was 37.0 (0-3577.0) in the patients with a negative test (p<0.001).

Conclusion: Although there is no statistical significance, the fact that PLR and ELR values are higher in patients with AD with positive allergy test suggest that these values can be used as a marker to predict allergy test positivity. Evaluation of hemogram parameters, which is an easily accessible test among AD patients, is extremely important for physicians working in this field.