Vaginal Smear Findings in Our Kidney Transplant Recipients

Vaginal Smear Findings


  • Utku ÖZGEN Pamukkale University School of Medicine



Vaginal smear, HPV, Kidney transplantation



The aim of this study was to evaluate the results of the smear tests in renal transplant recipients, determine the prevalence of abnormal outcomes and compare these patients with the general population in our center.


A total of 79 female patients who underwent renal transplantation at Pamukkale University were retrospectively evaluated. All patients were followed up during and after the surgical procedures by a gynecologist and the smear results were recorded periodically.


The mean time of Pap smear results after transplantation in kidney transplant recipients was 36.7±4.5 months. There was a significant difference between the two groups in terms of atrophic cervicitis. In transplantation group, 7 patients (8.86%) had LG-SIL, 3 (3.79%) had ASC-US and 1 (1.26%) had HG-SIL. In control group, the numbers are 3 (3.79%), 2 (2.53%) and 0, respectively. The difference between the patient and control groups in terms of LG-SIL results (7 (8.86%) vs 3 (3.79%) was statistically significant (p<0.05).


We predict that kidney transplant recipients are at higher risk for precancerous cervical lesions and cervical cancer development due to immunosuppressive therapy. Smear screening and HPV testing should be repeated periodically to detect or prevent precancerous lesions and cervical cancer.


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Kim, J.H., et al., Post-transplant malignancy: a burdensome complication in renal allograft recipients in Korea. Clin Transplant, 2014. 28(4): p. 434-42.

Ho, G.Y., et al., Natural history of cervicovaginal papillomavirus infection in young women. N Engl J Med, 1998. 338(7): p. 423-8.

Courtney, A.E., et al., The uptake of cervical cancer screening by renal transplant recipients. Nephrol Dial Transplant, 2009. 24(2): p. 647-52.

Solomon, D., et al., The 2001 Bethesda System: terminology for reporting results of cervical cytology. Jama, 2002. 287(16): p. 2114-9.

Ghazizadeh, S., M. Lessan-Pezeshki, and M.A. Nahayati, Human papilloma virus infection in female kidney transplant recipients. Saudi J Kidney Dis Transpl, 2011. 22(3): p. 433-6.

Madeleine, M.M., et al., HPV-related cancers after solid organ transplantation in the United States. Am J Transplant, 2013. 13(12): p. 3202-9.

Freiberger, D., L. Lewis, and L. Helfand, Human papillomavirus-related high-grade squamous intraepithelial lesions of the esophagus, skin, and cervix in an adolescent lung transplant recipient: a case report and literature review. Transpl Infect Dis, 2015. 17(1): p. 98-102.

Schlecht, N.F., et al., Human papillomavirus infection and time to progression and regression of cervical intraepithelial neoplasia. J Natl Cancer Inst, 2003. 95(17): p. 1336-43.

Veijalainen, O., et al., Human papillomavirus test with cytology triage in organized screening for cervical cancer. Acta Obstet Gynecol Scand, 2016. 95(11): p. 1220-1227.

Paternoster, D.M., et al., Human papilloma virus infection and cervical intraepithelial neoplasia in transplanted patients. Transplant Proc, 2008. 40(6): p. 1877-80.




How to Cite

ÖZGEN, U. (2023). Vaginal Smear Findings in Our Kidney Transplant Recipients: Vaginal Smear Findings. Chronicles of Precision Medical Researchers, 4(3), 406–409.