TY - JOUR AU - GULER AVCI, Gulhan AU - Altinisik Inan, Gonca AU - Aytac Arslan, Suheyla AU - Arslan, Alaettin AU - Guney, Yıldız PY - 2022/03/20 Y2 - 2024/03/29 TI - Treatment Results and Dosimetric Comparison of Synchronous Bilateral Breast Cancer with Helical Tomotherapy and Volumetric-Modulated Arc Radiotherapy: Radiotherapy in Bilateral Breast Cancer JF - Chronicles of Precision Medical Researchers JA - Chron Precis Med Res VL - 3 IS - 1 SE - Original Articles DO - 10.5281/zenodo.6371495 UR - https://chronpmr.com/index.php/cpmr/article/view/67 SP - 6-10 AB - <p><strong>Objective:</strong> The aim of this study is to present the short-term treatment results and dosimetric comparison of patients with synchronous bilateral breast cancer (SBBC) with helical tomotherapy (HT) and volumetric-modulated arc therapy (VMAT) &nbsp;by virtual treatment plans.</p><p><strong>Material and Methods:</strong> Twelve patients with SBBC who were diagnosed between June 2015 and June 2018, received adjuvant bilateral breast or chest wall RT were retrospectively analyzed. Seven of the patients were irradiated in helical Tomotherapy (Hi-Art ® Version 5.1.3) (HT) and the remaining 5 patients in Elekta Versa-HD v4.0 with VMAT. HT and VMAT plans were compared based on dose-volume histograms (DVH).</p><p><strong>Results:</strong> The median follow-up period of the patients was 19 months (range, 3-37 months). Nine (75%) patients had a locally advanced stage. Neoadjuvant chemotherapy was applied to 5 (41.6%) patients. One of 12 SBBC patients died due to systemic progression. Local control was achieved in other patients. Acute grade 1-2 dysphagia was observed in 5 and acute grade 1-2 radiodermatitis in 7 cases. When comparing VMAT and HT plans, statistically significant difference was revealed only in PTV D<sub>min</sub> and Lung V<sub>5</sub> values.&nbsp; Lung V<sub>5 </sub>was found statistically better in favor of helical tomotherapy (HT) and PTV D<sub>min</sub> in favor of Elekta Versa-VMAT.</p><p><strong>Conclusion: </strong>Various RT techniques as VMAT and helical tomotherapy can be approached in the management of rare cancers such as SBBC, and the patient-specific optimal plan should be selected.</p> ER -