Bibliometric Analysis On Non-Invasive Prenatal Testing

A Bibliometric Evaluation of Global Publication Trends, Citation Analysis, and Research Collaborations

Abstract

Aim: The study aimed to analyze and assess the global research development, collaborative network, prestigious literature and tendency of themes about Non-invasive prenatal testing(SDisease) (NIPT). 

Materials and Methods: A total of 1639 scientific publications between the years 2011-2025 were examined in this study from the Web Science (WoS) database databases. Country and institutional collaborations, co-citation networks, and keyword collocations were visualized for the data analysis in VOSviewer.

Results The publications in the area of NIPT were found to have increased over years. The PR China ranked the first both in terms of publications (n=384), with United States of America and United Kingdom being the countries with most significant international collaboration networks included respectively (n=206) and (n=199). The journal Prenatal Diagnosis contributed most, with 171 publications and 4,243 citations. Results Analysis of the Keywords showed that research interest has shifted from simple aneuploidy screening to technical (fetal fraction, mosaicism and next-generation sequencing) as well as social aspects (genetic counseling and ethical issues).

Conclusion: The NIPT field is a very active and mature area of research with an increasing volume of interest. The People’s Republic of China is the largest volume contributor, US and UK are in the hub of international collaboration and scientific influence. The emphasis in the field has changed from pure screening to more challenging issues like fetal fraction, mosaicism, genetic counseling and ethics.